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Vigene offers a comprehensive catalog of over 27,000 shRNA plasmid sets targeting the human genome. For most customers, we recommend performing initial testing with shRNAs in a viral vector backbone (i.e., transfect with the shRNA plasmids and validate in vitro). We guarantee at least 70% knockdown of your gene of interest with Vigene-designed shRNA vectors. Once you have determined the best shRNA for your experiments, we can then package your validated AAV vector for efficient gene knockdown in vivo.