AAV Zika ORFs

AAV Zika ORFs

AAV Zika Virus DNA ORFs

To aid Zika virus research, Vigene has cloned and packaged each of the individual 14 Zika virus ORFs into AAV. The Zika ORFs are non-pathogenic and can safely be used for research purposes. Zika virus has gained attention in recent years due to its outbreaks and association with human neurological disorders. There are currently no approved therapies or vaccines, so there is an urgent need to develop strategies that inhibit viral replication. In order to develop these strategies, it is imperative that we gain a better understanding of the function of the proteins involved in the process.

See All AAV Zika ORFs >

Zika Virus ORF Collection

The single-stranded (+) RNA Zika virus genome is translated into a 3,419 aa long polyprotein precursor, which is processed co- and post-translationally by both host and viral proteases. Click on any of the gene symbols listed in the table below for more information.

Note: We also have the full Zika virus genome available in plasmid or packaged in adenovirus.

Gene Symbol Protein
ancC anchored capsid protein C
C capsid protein C
preM membrane glycoprotein precursor M
pr protein pr
M membrane glycoprotein M
E envelope protein E
NS1 nonstructural protein NS1
NS2A nonstructural protein NS2A
NS2B nonstructural protein NS2B
NS3 nonstructural protein NS3
NS4A nonstructural protein NS4A
2K protein 2K
NS4B nonstructural protein NS4B
NS5 RNA-dependent RNA polymerase NS5

Zika Genome Organization

zika genome

What is Zika Virus?

Zika virus belongs to the Flavivirus genus, which also includes West Nile virus and dengue virus. Zika virus is transmitted primarily by the bite of infected Aedes mosquitoes, but it can also be passed through sex, blood transfusion, or from a pregnant woman to her fetus. Persons infected with Zika virus may be asymptomatic or have generally mild symptoms such as fever, rash, conjunctivitis, muscle and joint pain, malaise, or headache. These symptoms typically last for 2-7 days; however, infection during pregnancy may cause severe neurological brain defects such as microcephaly. There is currently no vaccine or treatment for Zika virus disease.

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FAQ

Which strain of Zika virus are your products derived from?
The Zika virus genome our products are derived from is Strain MR 766, which is the African Zika virus isolate. Please see the ViPR strain entry for more information. Please note that the Zika ORFs that we sell are non-pathogenic and are safe to use for research purposes.
Where can I find more information about Zika Virus?
For general information, please visit the CDC or WHO Zika virus pages. For information about the Zika genome, please see the Zika virus UniProt page.
What is Vigene’s guarantee?

Vigene guarantees that our Zika ORFs contain the specified Zika genome sequences. However, we cannot guarantee protein overexpression because it will depend on your experimental conditions.

1 to 10 of 15 Items

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  1. AAV9-ZIKV-2K
    ZV-2K-AAV9
    pAV-FH
    CMV
    FLAG, His
  2. AAV9-ZIKV-ancC
    ZV-ANC-AAV9
    pAV-FH
    CMV
    FLAG, His
  3. AAV9-ZIKV-C
    ZV-C-AAV9
    pAV-FH
    CMV
    FLAG, His
  4. AAV9-ZIKV-E
    ZV-E-AAV9
    pAV-FH
    CMV
    FLAG, His
  5. AAV9-ZIKV-M
    ZV-M-AAV9
    pAV-FH
    CMV
    FLAG, His
  6. AAV9-ZIKV-NS1
    ZV-NS1-AAV9
    pAV-FH
    CMV
    FLAG, His
  7. AAV9-ZIKV-NS2A
    ZV-NS2A-AAV9
    pAV-FH
    CMV
    FLAG, His
  8. AAV9-ZIKV-NS2B
    ZV-NS2B-AAV9
    pAV-FH
    CMV
    FLAG, His
  9. AAV9-ZIKV-NS3
    ZV-NS3-AAV9
    pAV-FH
    CMV
    FLAG, His
  10. AAV9-ZIKV-NS4A
    ZV-NS4A-AAV9
    pAV-FH
    CMV
    FLAG, His

1 to 10 of 15 Items

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per page
Set Descending Direction

To aid Zika virus research, Vigene has cloned and packaged each of the individual 14 Zika virus ORFs into AAV. The Zika ORFs are non-pathogenic and can safely be used for research purposes. Zika virus has gained attention in recent years due to its outbreaks and association with human neurological disorders. There are currently no approved therapies or vaccines, so there is an urgent need to develop strategies that inhibit viral replication. In order to develop these strategies, it is imperative that we gain a better understanding of the function of the proteins involved in the process.